Summary: Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy.Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with multiple Backpack Cloth Bag orthogonal validation approaches, we identified geldanamycin and its ana
Detection of Mechanically Separated Meat from Pork in Meat-Containing Foods by Targeted LC-MS/MS Analysis
Microscopy and calcium analysis have proven to be inadequate for the detection of mechanically separated meat (MSM) in meat-containing foods.Therefore, a pseudo-MRM-LC-MS/MS-based bottom-up assay was developed and validated for the detection of porcine MSM.In contrast to a comparable study on MSM from poultry, the studies on porcine MSM showed that